2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-130525
    Iodo-PEG3-N3 936917-36-1
    Iodo-PEG3-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Iodo-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Iodo-PEG3-N3
  • HY-130483
    Br-PEG3-C2-Boc 782475-37-0
    Br-PEG3-C2-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Br-PEG3-C2-Boc
  • HY-138524
    Thiol-PEG2-acid 1379649-73-6
    Thiol-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thiol-PEG2-acid
  • HY-140476
    Boc-NH-PEG1-CH2COOH 142929-49-5 ≥98.0%
    Boc-NH-PEG1-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG1-CH2COOH
  • HY-W094307
    Methyl-PEG3-bromide 72593-77-2 98.23%
    Methyl-PEG3-bromide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyl-PEG3-bromide
  • HY-140928
    Biotin-PEG4-amino-t-Bu-DADPS-C3-alykne 2241685-22-1
    Biotin-PEG4-amino-t-Bu-DADPS-C3-alykne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Biotin-PEG4-amino-t-Bu-DADPS-C3-alykne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Biotin-PEG4-amino-t-Bu-DADPS-C3-alykne
  • HY-114512
    m-PEG1-NHS ester 1027371-75-0
    m-PEG1-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG1-NHS ester
  • HY-135048
    Mal-PEG4-OH 1421933-37-0
    Mal-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-PEG4-OH
  • HY-133479
    Tetrazine-Ph-NHCO-C3-NHS ester 1244040-64-9 98.40%
    Tetrazine-Ph-NHCO-C3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Tetrazine-Ph-NHCO-C3-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Tetrazine-Ph-NHCO-C3-NHS ester
  • HY-138734
    Propargyl-PEG2-NHS ester 2512228-06-5 ≥98.0%
    Propargyl-PEG2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG2-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG2-NHS ester
  • HY-133174
    Biotin-PEG5-azide 1163732-89-5
    Biotin-PEG5-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTAC. Biotin-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Biotin-PEG5-azide
  • HY-140899
    Biotin-PEG8-amine 2183447-27-8
    Biotin-PEG8-amine is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG8-amine
  • HY-134721
    Amine-PEG3-Desthiobiotin 2237234-71-6 99.87%
    Amine-PEG3-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amine-PEG3-Desthiobiotin
  • HY-140892
    Biotin-PEG12-NHS ester 1934296-88-4 99.31%
    Biotin-PEG12-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG12-NHS ester
  • HY-130828
    Bis-PEG25-NHS ester 2221948-96-3 99.75%
    Bis-PEG25-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG25-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Bis-PEG25-NHS ester
  • HY-W040257
    NH2-PEG6-CH2CH2COOH 905954-28-1
    NH2-PEG6-CH2CH2COOH is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). NH2-PEG6-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG6-CH2CH2COOH
  • HY-140759
    Azido-PEG10-NHS ester 2801772-86-9 98.03%
    Azido-PEG10-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG10-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG10-NHS ester
  • HY-W040244
    Boc-NH-PEG6-CH2CH2COOH 882847-13-4
    Boc-NH-PEG6-CH2CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC). Boc-NH-PEG6-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG6-CH2CH2COOH
  • HY-43614
    Propynol Ethoxylate 3973-18-0
    Propynol Ethoxylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propynol Ethoxylate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propynol Ethoxylate
  • HY-140571
    N-Mal-N-bis(PEG2-NHS ester) 2182601-73-4 98.86%
    N-Mal-N-bis(PEG2-NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Mal-N-bis(PEG2-NHS ester)
PROTAC Linkers Isoform Comparison

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