2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-122456
    Fmoc-PEG4-NHS ester 1314378-14-7 98.62%
    Fmoc-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-PEG4-NHS ester
  • HY-130828
    Bis-PEG25-NHS ester 2221948-96-3 99.75%
    Bis-PEG25-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG25-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Bis-PEG25-NHS ester
  • HY-W096121
    PEG3 67439-82-1 98.0%
    PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    PEG3
  • HY-W037355
    4-Maleimidobutyric acid 57078-98-5 99.86%
    4-Maleimidobutyric acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    4-Maleimidobutyric acid
  • HY-130151
    m-PEG7-CH2CH2COOH 1093647-41-6 99.39%
    m-PEG7-CH2CH2COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG7-CH2CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG7-CH2CH2COOH
  • HY-W042625
    Hexaethylene glycol monomethyl ether 23601-40-3 98.77%
    Hexaethylene glycol monomethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Hexaethylene glycol monomethyl ether
  • HY-W754588
    exo-BCN-L-Lysine 1384100-45-1
    exo-BCN-L-Lysine is a Click Amino Acid that can be used as a linker in the synthesis of PROTAC molecules. exo-BCN-L-Lysine contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    exo-BCN-L-Lysine
  • HY-141274
    4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenol 58884-35-8
    4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenol is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    4-(6-Methyl-1,2,4,5-tetrazin-3-yl)phenol
  • HY-W005828
    9-(Boc-amino)nonanoic acid 173435-78-4 ≥98.0%
    9-(Boc-amino)nonanoic Acid is an alkane chain with terminal carboxlic acid and Boc-protected amino groups. 9-(Boc-amino)nonanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
    9-(Boc-amino)nonanoic acid
  • HY-126974
    Propargyl-PEG3-NHS ester 1428629-71-3
    Propargyl-PEG3-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG3-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG3-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG3-NHS ester
  • HY-133393
    Azido-PEG6-azide 1243536-56-2
    Azido-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG6-azide
  • HY-42151
    Mal-amido-PEG2-C2-acid 756525-98-1 99.80%
    Mal-amido-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Mal-amido-PEG2-C2-acid
  • HY-116006
    Bis-PEG5-acid 439114-13-3 99.90%
    Bis-PEG5-acid (PROTAC Linker 36) is a PROTAC linker, which belongs to a polyethylene glycol (PEG) linker. Bis-PEG5-acid (PROTAC Linker 36) can be used in the synthesis of the CP5V. CP5V is a PROTAC, and specifically degrades Cdc20.
    Bis-PEG5-acid
  • HY-W007529
    Boc-6-aminohexanoic acid 6404-29-1 98.0%
    Boc-6-aminohexanoic acid is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-6-aminohexanoic acid
  • HY-W010975
    Fmoc-Lys-OH hydrochloride 139262-23-0 99.84%
    Fmoc-Lys-OH hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys-OH hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-Lys-OH hydrochloride
  • HY-130216
    THP-PEG3-OH 60221-37-6 98.67%
    THP-PEG3-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    THP-PEG3-OH
  • HY-130147
    Propargyl-PEG5-OH 1036204-60-0
    Propargyl-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG5-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG5-OH
  • HY-134704
    Biotin-PEG4-SH 2762393-22-4
    Biotin-PEG4-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG4-SH
  • HY-140470
    Boc-NH-PEG8-CH2CH2COOH 1334169-93-5 99.94%
    Boc-NH-PEG8-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG8-CH2CH2COOH
  • HY-140004
    Azide-PEG3-Tos 178685-33-1 99.15%
    Azide-PEG3-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG3-Tos is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azide-PEG3-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG3-Tos
PROTAC Linkers Isoform Comparison

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